RS-485標準也是一種平衡傳輸方式的串行接口標準，它和RS-422A兼容并且擴展了RS-422A的功能。
RS-485的電氣特性：邏輯“1”以兩線間的電壓差為＋(2－6)V表示；邏輯“0”以兩線間的電壓差為-(2-6)V表示。接口信號電平比RS-232C降低了，就不易損壞接口電路的芯片，且該電平與TTL電平兼容，可方便與TTL電路連接。數據最高傳輸速率為10Mbps。RS-485接口是采用平衡驅動器和差分接收器的組合，抗共模干擾能力增強，即抗干擾性好。RS-485接口的最大傳輸距離標準值為4000英尺，實際上可達3000米。RS-485接口在總線上是允許連接多達128個收發器，具有多站能力，用戶可以利用它建立起設備網絡。RS-485接口由于具有良好的抗干擾性、傳輸距離長和多站能力等優點使其成為首選的串行接口。
 
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